№4 (16) 2019

The article describes the cooling effect on the ploidometric profile of hepatocytes in experimental animals. Changes in the ploidy of hepatocytes of white rats depending on the cooling environment were determined.
Keywords: hypothermia, liver, ploidy.

The article presents a description of the results of physical activity assessment among students of the medical university. At the assessment, the physical activity level of students of the 3–5 year in ASMU was studied.
Keywords: physical activity of students, physical activity level, healthy lifestyle.

The paper presents an analysis of the archive histories of diseases of postmenopausal patients who were examined and treated in the period from 2012 to 2017. Predominantly asymptomatic course of endometrium pathological processes in elderly and senile patients was revealed. Polyps prevail in the structure of endometrium pathology, the frequency of endometrial carcinomas is higher than the population ones.
Keywords: endometrium, postmenopause.

The article describes the results of a comparative analysis of the documentation of multifetal pregnancies and birthgiving of women after assisted reproductive technologies. In the course of studying 63 birth histories in the Maternity Hospital No.2 of Barnaul from 2016 to 2018, the most frequent complications of the analyzed pregnancies and subsequent birthgiving were identified.
Keywords: multifetal pregnancy, assisted reproductive technologies.

The article describes the results of comparative analysis of the combination of causes in the group of women with realized premature birth and the group of women who gave birth in time. In the course of the study, individual records of pregnant women and the history of their childbirth were analyzed. Risk factors and perinatal prognosis for newborns were determined.
Keywords: premature birth, cervical insufficiency, primary fetoplacental insufficiency, perinatal mortality.

The article presents the influence of indapamide group drugs on the treatment of arterial hypertension. The comparative analysis of indapamide diuretics in the form of retard tablets by manufacturers, additives and bioavailability was carried out. Conclusions about the advantages of the retard tablet drug form for the treatment of arterial hypertension were made.
Keywords: arterial hypertension, diuretics, indapamide.

This article presents a study of the correlation between the ploidy of nucleus of tumor cells of renal cell carcinoma and some prognosis factors, histological type of cancer. We conclude that the study of such parameter as ploidy can be useful as an additional diagnostic method. This article may be of interest primarily to oncologists, pathomorphologists.
Keywords: ploidometry, renal cell carcinoma, DNA uptake ratio.

The article describes the results of the survey using the Beighton score in order to identify the connection between the occurrence of pathology of ENT organs and the degree of joint hypermobility. The study examined the prevalence of connective tissue dysplasia syndrome in people with ENT organ diseases. The article also considers the role of connective tissue dysplasia in the clinical course of diseases such as cheiloschisis and polyposis.
Keywords: connective tissue dysplasia, cheiloschisis, polyposis.

The article describes the risk factors of antenatal full-term fetal death, revealed in the course of clinical and statistical analysis of two groups of women. A scale for assessing the risk of antenatal fetal death has been developed. The analysis of its effectiveness was carried out with the help of telemedicine technology – the automated workplace of the doctor “Register of pregnant women” after the introduction of the risk assessment scale.
Keywords: antenatal fetal death, risk, analysis.

The article describes the results of the study aimed at identifying the connection between menstrual cycle disorders and congenital connective tissue deficiency. Women included in groups on the criterion of presence of undifferentiated phenotypic and visceral signs of connective tissue dysplasia, menstrual ovarian dysfunction in the history were interviewed.
Keywords: connective tissue dysplasia, menstrual dysfunction.

The article presents the reasoning on the possibility of learning endocrinology in the simulation center, based on both literature data on this issue and our own practical experience.
Keywords: endocrinology, simulation training, continuing professional education.

The article is devoted to the description of wounds obtained from the impact of sharp objects in corpses. The archival material of the Barnaul morgue “Altai Regional Bureau of Forensic Medicine” for the period from 2012 to 2017 was used. A detailed analysis of morphological characteristics of wounds obtained from sharp objects in corpses during this period of time with subsequent comparison and identification of compliance with Order N 346n from 12.06.2010 “On approval of the procedure for the organization and production of forensic medical examinations in state forensic institutions of the Russian Federation” is presented.
Keywords: forensic medicine, description of wounds, sharp objects.

The article describes the results of the comparative analysis of women of childbearing age with the diagnosis of polycystic ovary syndrome with signs of mesenchymal dysplasia and women without obvious manifestations of signs of mesenchymal dysplasia. In the course of the research, the information about the heredity of all patients, the presence of certain signs of mesenchymal dysplasia, asthenoneurotic syndrome were studied.
Keywords: polycystic ovary syndrome, mesenchymal dysplasia, connective tissue.

53 school-age children diagnosed with gastroesophageal reflux disease, established on the basis of a comprehensive clinical and endoscopic examination, including 31 children with erosive and 22 with non-erosive forms of disease were examined. It is shown that the average score when using the Gerd-Q questionnaire in the group of patients with erosive GERD is significantly higher than in the group with non-erosive GERD.
Keywords: gastroesophageal reflux disease, children, erosive esophagitis, Gerd-Q, quality of life.

The article describes the results of a statistical analysis of death data in cases of car injuries. In the course of the study, the archive material of the morgue of Barnaul was used. The dynamics of mortality, the frequency of occurrence of characteristic morphological signs in a car injury was determined.
Keywords: car injury.

The article describes a statistical analysis of death data when drowning in water. In the course of the study, the archive material of the morgue of Barnaul was used. The dynamics of mortality, the frequency of occurrence of characteristic morphological signs when drowning in water were determined.
Keywords: drowning, mechanical asphyxia.

Gestational diabetes mellitus (GDM) is a pathology that occurs in a significant number of women during pregnancy, usually develops in the third trimester (between 24 and 28 weeks) and usually disappears after the birth of the child. This disease can affect both the health of the mother and the health of the fetus. The GDM is a topical and discussed problem from the medical and social point of view. Also, GDM significantly increases the frequency of adverse outcomes for both the mother and the fetus.
Keywords: gestational diabetes mellitus, population, morbidity.

The article describes the results of the analysis of rat nucleolar organizers in aqueous hypothermia. In the course of the work, the morphofunctional activity of the nucleolar apparatus depending on the duration of hypothermia was studied. Adaptive processes of the nucleolar apparatus in the posthypothermic period were determined.
Keywords: hypothermia, rats, liver, nucleus.

The paper describes the problem of renal cell carcinoma and the possibility of expanding the diagnostic potential by studying the morphometric parameters of cell nuclei.
Keywords: renal cell carcinoma, morphometric parameters, diagnosis.

The article describes the results of the study of the presence of connective tissue dysplasia among sportspersons, as well as data to determine the relationship between individual achievements in sports and presence of connective tissue dysplasia in sportspersons. In the course of the study, 292 students from universities in Altai Krai were surveyed using a questionnaire.
Keywords: dysplasia, sportspersons, signs, dependence.

The article describes the results of the study of the relationship between skin pigmentation and phenotypic signs of connective tissue dysplasia. The study revealed a violation of pigment exchange in students with signs of mesenchymal dysplasia.
Keywords: pigmentation, moles, mesenchymal dysplasia, pigment exchange.

The problem of iodine deficiency diseases (IDD) in terms of level and scale is relevant in many countries of the world, including Russia. The lack of iodine in the diet of the population leads to a number of diseases, a significant proportion of which is the pathology of the thyroid gland, as it is an obligatory structural component of the thyroid hormones that ensure the full development and functioning of the human body.
Keywords: iodine, iodine deficiency, thyroid gland, iodine deficiency diseases, iodine prevention.

The article describes the results of a statistical analysis of death in a gunshot injury. In the course of the study, the archive material of the morgue of Barnaul was used. The dynamics of mortality, the frequency of occurrence of morphological signs characteristic of a gunshot injury were determined.
Keywords: gunshot injury.

The article describes the results of the study of the medical and social portrait of the female inhabitants of Altai Krai, who have suffered near miss cases associated with severe preeclampsia/eclampsia and massive obstetric haemorrhages, and analyzes the structure of massive obstetric haemorrhages from the perspective of a risk strategy. The clinical and statistical analysis of medical records of women who early gave birth due to critical obstetric condition before and after the development of the risk strategy was carried out.
Keywords: medical and social portrait, near-miss case, risk strategy.

Acute paralysis is a condition that requires a quick, thorough and correct diagnosis to choose the right treatment tactics, the timely start of which allows to achieve recovery or reduce the severity of the consequences of the disease. This article describes a clinical case of hypokalemic periodic paralysis, which is a fairly rare disease capable of leading to certain difficulties in diagnosis, but with proper treatment, there is a complete regression of the clinic.
Keywords: hypokalemia, hypokalemic periodic paralysis, paroxysmal myoplegia.

The purpose of the work is to determine the most common pathology of the visual analyzer and its manifestations in CTD and to identify concomitant pathologies from other organ systems. A survey was conducted among people with CTD, the results of which served as a basis for the identification of people with a visual disorder. Survey results: the number of surveyed amounted to 98 people, of them: with CTD – 33 people, without CTD – 65 people. Of 33 people with CTD, there were other diseases of the visual analyzer: myopia – 21 people (63%), color blindness – 4 people (12%), retinal detachment – 6 people (24%), nystagmus – 1 person (4%), strabismus – 5 people (15%). The number of students without CTD amounted to 65 people, 44 of them have diseases of the visual analyzer: 3 people – signs of nystagmus (7%), 18 people – signs of myopia (41%), 9 people – signs of strabismus (21%), 4 people – signs of retinal detachment (9%) and 10 people – signs of hypermetropia (22%). It was revealed that myopia in the majority of students manifests in school years (88%) and is accompanied by astigmatism (17%). From the above, myopia is the most common pathology of the visual analyzer. On the part of other organ systems in students with CTD, it was revealed that non-progressive myopia and headaches of tension are more common in people with mild degree of joint hypermobility – 67% (headaches – 78%).
Keywords: connective tissue dysplasia, myopia, non-progressive myopia, astigmatism, headache of tension, mild joint hypermobility.